Therapeutic naphthenic oil and its active fraction.

Therapeutic naphthenic oil and its active fraction....

Therapeutic naphthenic oil and its active fraction.

Fraction of naphthenic petroleum Naphthenic hydrocarbon - one of the few that have an effective therapeutic effect, has long been used for medical purposes, but it is still not clear which of its components have the greatest biological activity.

In the present work, a study was made of the chemical composition of naphthenic petrolemma and the active therapeutic components isolated from it. The need for such an investigation is due to the expansion of the Naftalan resort, where, just like in the Azerbaijan Research Institute (AzNII), balneology and physical methods of treatment for them. CM. Kirov, naftalan oil is widely used for medicinal purposes.

To study the composition of the naphthenic petroleum, gas-liquid chromatography, adsorption chromatography on silica gel and alumina, vacuum fractionation, thermodiffusion separation, liquid selective catalytic dehydrogenation, selective isomerization, IR and UV spectroscopy, as well as masses spectrometry. .

Chromatographic separation of the naphthenic ptolemium after its demulsification was carried out by the accelerated adsorption method used in the investigation of the hydrocarbon composition of mineral oils with naphthenic hydrocarbons. The structural group composition of the naphthenic hydrocarbons was calculated by the n-d-M method, and the aromatic hydrocarbons by the Heiselwood method. For a wide fraction of naphthenic hydrocarbons, extracted from naphthenic petroleum, the presence in the molecule of an average of 2.5 rings and the predominance of carbon atoms in the rings (Cq) relative to the content of the latter in the side chains (Cn) is characteristic. The ratio of Ck to Cn is about 1.5. Aromatic hydrocarbons with a total number of rings, increasing from 2.6 to 4.7, are hybrid structures in which the cyclicity increases due to aromatic rings (from 0.9 to 3.1) with an almost constant number of naphthenic rings. The increase in the degree of condensation of aromatic hydrocarbons can be judged by a significant increase in the deficiency of hydrogen atoms (from 8.4 to 18.5). The ratio of aromatic rings to naphthenic in aromatic hydrocarbon molecules increases cyclically with the transition from light fractions to heavy ones.

Resins extracted from naphthenic petroleum by chromatographic separation are characterized by high molecular weight and density; they contain sulfur, nitrogen and oxygen in their composition. As can be seen from the data given, the characteristics of individual hydrocarbon groups of naphthenic petroleum give only general, averaged information about its composition and do not reflect the complexity and diversity of the hydrocarbons contained in this oil. Therefore, in the study of naphthenic and aromatic hydrocarbons, narrow fractions isolated by vacuum distillation and thermal diffusion separation were used.

Of all the components of naphthenic petroleum, the most active biological activity is produced by naphthenic hydrocarbons. They have a positive effect on a number of physiological functions of the body and do not have toxic properties.

A wide fraction of naphthenic hydrocarbons was studied in two ways: by dividing it into narrow fractions by vacuum distillation and by thermodiffusion (the presence of paraffinic hydrocarbons was preliminarily determined and purified from them. To this end, a wide fraction of naphthenic hydrocarbons, tested for the absence of aromatic hydrocarbons by the Nastyukov reaction and - The presence in the IR spectrum of characteristic bands of 650-900 cm-1, subjected to low-temperature dewaxing, selective solvents and urea treatment. Dewaxing in selective solvents was carried out at -60 ° C in a mixture of acetone: benzene: toluene (35:35:30) with a preliminary thermal treatment of a solution of naphthenic hydrocarbons at 60 ° C. Investigations by IR spectroscopy have shown that long paraffin chains containing more than six

methylene groups ((CH2) n-CH3, n> 6) can be detected in the 725-723 cm-1 band, starting from the fraction 350-420 ° C, the band intensity increases with the boiling temperature of the fraction. Paraffin chains containing at least four methylene groups ((CH2) n-CH3, n> 4) are represented in all fractions by an intense band of 1302-1309 cm-1. In the fractions 240-300 and 300-350 ° C, n-butyl units are found along the 732-736-cm-1 band.

Isopropyl units are represented in the first three fractions by the band 1169-1167 cm-1; The second band (916-919 cm-1) characteristic for these links is present only in the first two fractions. The presence of tertiary carbon atoms in the 500-525 and> 525 ° C fractions of the 1340 and 1210 cm-1 bands characteristic of the methine unit CH-, for the fraction> 525 ° C, the first of the bands is represented as a very weak arm on the band 1374 cm-1, and the second band is of low intensity. The bands 961-972 cm-1 indicate the presence of condensed polymethylene rings.

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